필터
“2064” 에 대한 검색 결과 5 건
정렬 기준:
알파벳순 (A-Z)
베스트셀러
B6-hHER2 (hERBB2)
제품 ID:
C001627
계통(Strain):
C57BL/6NCya
상태:
설명:
Epidermal growth factor receptor 2 (ERBB2), also known as HER2 or Neu protein, encoded by the ERBB2 gene, is a member of the ErbB receptor tyrosine kinase family. ERBB2 gene expression is subject to complex regulation, influenced by diverse transcription factors and signaling pathways, and is normally expressed at low levels in various epithelial tissues, including the breast, ovary, and gastrointestinal tract [1]. HER2, a transmembrane receptor tyrosine kinase, functions at the cell surface, primarily through heterodimerization with other epidermal growth factor receptor family members, such as HER3. This activation initiates downstream signaling pathways, including PI3K/Akt and MAPK, which regulate cell growth, proliferation, differentiation, and migration [1]. In tumor tissues, ERBB2 gene amplification or overexpression is frequently observed, particularly in solid tumors such as breast, gastric, and ovarian cancers. Elevated HER2 expression is strongly associated with tumorigenesis, progression, invasion, metastasis, and poor patient prognosis, establishing it as a key prognostic marker and therapeutic target in breast and other cancers [2-4]. Targeted therapies against HER2, including monoclonal antibodies such as trastuzumab and pertuzumab, and small molecule tyrosine kinase inhibitors, have become essential treatments for patients with HER2-positive breast cancer and other malignancies [4].
The B6-hHER2(ERBB2) mouse is a humanized model constructed using gene editing technology, where the mouse HER2 extracellular domain was replaced with the human HER2 extracellular domain. Homozygous B6-hHER2(ERBB2) mice are viable and fertile. This model can be used for studying the pathological mechanisms and therapeutic approaches of related cancers, and for the development of HER2-targeted drugs.
Epidermal growth factor receptor 2 (ERBB2), also known as HER2 or Neu protein, encoded by the ERBB2 gene, is a member of the ErbB receptor tyrosine kinase family. ERBB2 gene expression is subject to complex regulation, influenced by diverse transcription factors and signaling pathways, and is normally expressed at low levels in various epithelial tissues, including the breast, ovary, and gastrointestinal tract [1]. HER2, a transmembrane receptor tyrosine kinase, functions at the cell surface, primarily through heterodimerization with other epidermal growth factor receptor family members, such as HER3. This activation initiates downstream signaling pathways, including PI3K/Akt and MAPK, which regulate cell growth, proliferation, differentiation, and migration [1]. In tumor tissues, ERBB2 gene amplification or overexpression is frequently observed, particularly in solid tumors such as breast, gastric, and ovarian cancers. Elevated HER2 expression is strongly associated with tumorigenesis, progression, invasion, metastasis, and poor patient prognosis, establishing it as a key prognostic marker and therapeutic target in breast and other cancers [2-4]. Targeted therapies against HER2, including monoclonal antibodies such as trastuzumab and pertuzumab, and small molecule tyrosine kinase inhibitors, have become essential treatments for patients with HER2-positive breast cancer and other malignancies [4].
The B6-hHER2(ERBB2) mouse is a humanized model constructed using gene editing technology, where the mouse HER2 extracellular domain was replaced with the human HER2 extracellular domain. Homozygous B6-hHER2(ERBB2) mice are viable and fertile. This model can be used for studying the pathological mechanisms and therapeutic approaches of related cancers, and for the development of HER2-targeted drugs.
B6-huCFTR*F508del/huHER2
제품 ID:
C001926
계통(Strain):
C57BL/6NCya
상태:
설명:
The B6-huCFTR*F508del/huHER2 mouse is a humanized disease model obtained by mating huCFTR-F508del mice (catalog No.: C002092) with B6-huHER2 (huERBB2) mice (catalog No.: C001627). Homozygous huCFTR-F508del mice need to be fed with intestinal cleansers after 3 weeks of age to maintain their survival. This model can be used for research on the pathological mechanisms and treatment methods of cystic fibrosis (CF) and cancer, as well as for the development of CFTR/HER2-targeted drugs.
The B6-huCFTR*F508del/huHER2 mouse is a humanized disease model obtained by mating huCFTR-F508del mice (catalog No.: C002092) with B6-huHER2 (huERBB2) mice (catalog No.: C001627). Homozygous huCFTR-F508del mice need to be fed with intestinal cleansers after 3 weeks of age to maintain their survival. This model can be used for research on the pathological mechanisms and treatment methods of cystic fibrosis (CF) and cancer, as well as for the development of CFTR/HER2-targeted drugs.
huSLC6A19/Pah-R243Q
제품 ID:
C002064
계통(Strain):
C57BL/6NCya
상태:
설명:
The huSLC6A19/Pah-R243Q mouse was generated by replacing the endogenous mouse Slc6a19 gene sequence (from the start codon to the 3'UTR) with the human SLC6A19 gene sequence (from the start codon to the 3'UTR) in the Pah-R243Q mice (catalog No.: C001738). This model is suitable for research on phenylketonuria (PKU), amino acid metabolism disorders, and the screening and preclinical evaluation of SLC6A19 inhibitors.
The huSLC6A19/Pah-R243Q mouse was generated by replacing the endogenous mouse Slc6a19 gene sequence (from the start codon to the 3'UTR) with the human SLC6A19 gene sequence (from the start codon to the 3'UTR) in the Pah-R243Q mice (catalog No.: C001738). This model is suitable for research on phenylketonuria (PKU), amino acid metabolism disorders, and the screening and preclinical evaluation of SLC6A19 inhibitors.
Vegfd-KO
제품 ID:
S-KO-02064
계통(Strain):
C57BL/6NCya
상태:
설명:
Vegfd is located on chromosome X of mice. Nuclease Technology was used to design sgRNA; Vegfd knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Vegfd is located on chromosome X of mice. Nuclease Technology was used to design sgRNA; Vegfd knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Dnajc1-flox
제품 ID:
S-CKO-02064
계통(Strain):
C57BL/6JCya
상태:
설명:
Dnajc1 is located on chromosome 2 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Dnajc1 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Dnajc1 is located on chromosome 2 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Dnajc1 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
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