huINHBE/huCIDEB(2) Mouse
제품명
huINHBE/huCIDEB(2) Mouse
제품 ID
C002025
품종 계통
C57BL/6N;6JCya-Cidebem1Gt(ROSA)26Sortm1(hCIDEB)Inhbetm1(hINHBE)/Cya
Backgroud
C57BL/6N;6JCya
상태
이 마우스 계통을 논문에서 사용할 경우, “huINHBE/huCIDEB(2) Mouse (카탈로그 번호 C002025)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
유전자 별칭
--
염색체
Chr 14, Chr 12
MGI ID
Datasheet
품종 계통 설명
The huINHBE/huCIDEB(2) mice are a double-gene humanized model obtained by mating huINHBE mice (Catalog Number: C001533) with huCIDEB(2) mice (Catalog Number: C001990). This model is applicable to the study of pathogenesis of various liver diseases, such as Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Metabolic Dysfunction-Associated Steatohepatitis (MASH), cirrhosis, and viral hepatitis (HCV, HBV), as well as the research on obesity and metabolic diseases associated with improper fat distribution and storage. It can also be used for the screening, development, and preclinical evaluation of INHBE/CIDEB-targeted therapeutics.
변형 전략
The huINHBE/huCIDEB(2) mice are a double-gene humanized model obtained by mating huINHBE mice (Catalog Number: C001533) with huCIDEB(2) mice (Catalog Number: C001990).
Figure 1. Gene editing strategy of huINHBE mice. The sequences from the ATG start codon to 3'UTR of mouse Inhbe were replaced with the sequences from the ATG start codon to 3'UTR of human INHBE.
Figure 2. Gene editing strategy for huCIDEB(2) mice. The sequence from upstream of exon 1 of the human CIDEB gene to downstream of exon 5 of the human CIDEB gene was cloned into intron 1 of ROSA26 in reverse orientation. The Cideb gene contains five exons, with the ATG start codon located in exon 1 and the TAA stop codon located in exon 5. The coding region of exon 2 was selected as the target site.
응용 분야
Screening, development, and preclinical evaluation of INHBE/CIDEB-targeted drugs;
Research on the pathological mechanisms and treatment methods of various liver diseases, such as Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Metabolic Dysfunction-Associated Steatohepatitis (MASH), cirrhosis, and viral hepatitis (HCV, HBV);
Research on metabolic syndrome, obesity, and metabolic diseases related to improper fat distribution and storage.
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